Weil R, Koep L J, Starzl T E
Arch Surg. 1979 Feb;114(2):178-80. doi: 10.1001/archsurg.1979.01370260068010.
Between 1970 and 1978, eight hepatic adenomas were resected. Four of the eight patients took oral contraceptive pills before the hepatic adenoma was identified; one patient was male. Four patients had evidence of bleeding at the time of presentation. The original histologic diagnosis in the first five patients was malignant hepatoma. There has been no known recurrence of tumor and all patients are well. The use of oral contraceptives in these patients has been prohibited. Formal anatomic resection is recommended for hepatic adenoma when this procedure can be done without mortality or serious morbidity; however, in the future, less drastic treatments, such as occlusion of the hepatic arterial circulation to the tumor or discontinuation of oral contraceptives, may prove as effective as tumor resection.
1970年至1978年间，共切除了8例肝腺瘤。8例患者中有4例在肝腺瘤被发现之前服用口服避孕药；1例患者为男性。4例患者在就诊时有出血迹象。前5例患者最初的组织学诊断为恶性肝癌。目前尚无肿瘤复发的报道，所有患者情况良好。这些患者已被禁止使用口服避孕药。当能在不导致死亡或严重并发症的情况下进行手术时，建议对肝腺瘤进行正规的解剖切除；然而，在未来，诸如阻断肿瘤的肝动脉循环或停用口服避孕药等不太激进的治疗方法，可能会被证明与肿瘤切除同样有效。
