Catalano P W, Early M E, Topolosky H W, Martin E W, Carey L C
Cancer. 1977 Feb;39(2):587-91. doi: 10.1002/1097-0142(197702)39:2<587::aid-cncr2820390232>3.0.co;2-d.
The authors add six patients with focal nodular hyperplasia of the liver to the increasing number reported. All had ingested hormones as contraceptives for periods of from one and one-half to seven years. In five patients, the initial manifestation was massive intraabdominal hemorrhage and hypovolemic shock. Five of the six underwent emergency laparotomy for control of hemorrhage. Five patients are living; one patient died six days postoperatively because of coagulopathy. The single diagnostic procedure which proved valuable was liver scan. When hepatic focal nodular hyperplasia is disclosed, we recommend limited resection without ligation of the hepatic artery. Ingestion of birth control hormones should be prohibited.
作者在报告数量不断增加的情况下，又增加了6例肝脏局灶性结节性增生患者。所有患者都曾服用激素作为避孕药，服用时间为1.5至7年。5例患者最初的表现为腹腔内大量出血和低血容量性休克。6例患者中有5例接受了急诊剖腹手术以控制出血。5例患者存活；1例患者术后6天因凝血障碍死亡。唯一被证明有价值的诊断方法是肝脏扫描。当发现肝脏局灶性结节性增生时，我们建议进行有限切除，不结扎肝动脉。应禁止服用避孕药激素。
