Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF.
J Med Screen. 2011;18(2):96-102. doi: 10.1258/jms.2011.011065.
To assess the feasibility and acceptability of randomizing the phased introduction of the extension of the invited age range in the National Health Service (NHS) Breast Screening Programme in England from 50-70 to 47-73 years.
Six volunteer breast screening units (BSUs) in England.
Cluster-randomized trial of invitation versus no invitation for breast screening.
women aged 47-49 and 71-73 years in screening batches randomized between 1 June 2009 and 31 May 2010.
workload, screening uptake among women invited, self-referrals among women not invited, and screening outcomes among women invited.
A total of 312 screening batches (clusters) were randomized including 60,708 women. Screening uptake was 63% in women aged 47-49 and 62% in women aged 71-73. Those who attended screening in the younger age group were more likely to be recalled for assessment than older attendees (7.5% vs. 3.0%) but less likely to be diagnosed with breast cancer (0.5% vs. 1.1%). Among women not invited, 0.2% of those aged 47-49 and 6.8% of those aged 71-73 self-referred for screening. Despite the extra workload BSUs largely coped although there was some slippage in round lengths and other targets.
No major problems of feasibility or acceptability of randomization were found. This pilot study has informed the randomized phasing-in of the age extension across the whole of England.
评估在英格兰国民保健署（NHS）乳房筛查计划中将邀请年龄范围从 50-70 岁扩展到 47-73 岁分阶段引入的可行性和可接受性。
英格兰六个志愿乳房筛查单位（BSU）。
采用邀请与不邀请进行乳房筛查的聚类随机试验。
2009 年 6 月 1 日至 2010 年 5 月 31 日期间随机分配到筛查批次的 47-49 岁和 71-73 岁的女性。
共随机分配了 312 个筛查批次（聚类），包括 60708 名女性。47-49 岁女性的筛查参与率为 63%，71-73 岁女性的筛查参与率为 62%。在年龄较小的组中参加筛查的女性比年龄较大的女性更有可能被召回评估（7.5%比 3.0%），但被诊断患有乳腺癌的可能性较小（0.5%比 1.1%）。在未被邀请的女性中，47-49 岁的女性中有 0.2%，71-73 岁的女性中有 6.8%自我推荐进行筛查。尽管工作量增加，但 BSUs 基本上能够应对，尽管在轮次长度和其他目标方面存在一些拖延。
随机分组没有发现重大的可行性或可接受性问题。这项试点研究为英格兰全国范围内年龄扩展的分阶段实施提供了信息。
