Departament de Products Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, E-08028 Barcelona, Spain.
Molecules. 2011 Aug 18;16(8):7097-104. doi: 10.3390/molecules16087097.
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine.
加兰他敏，一种乙酰胆碱酯酶抑制剂，以氢溴酸盐盐（Razadyne ® ，Reminyl ® ）的形式上市，用于治疗阿尔茨海默病（AD），它是从石蒜科植物中获得的，特别是那些属于 Leucojum 、 Narcissus 、 Lycoris 和 Ungernia 属的植物。加兰他敏的需求不断增长，促使人们寻找这种化合物的新来源，以及用于治疗 AD 的其他生物活性生物碱。在本文中，我们报道了新生物碱 11β-羟基加兰他敏的分离，它是以前分离的生物碱哈兰汀的差向异构体，这是通过 NMR 技术鉴定的。已经表明，11β-羟基加兰他敏具有重要的体外乙酰胆碱酯酶抑制活性。此外，Hippeastrum papilio 产生了大量的加兰他敏。
