Berkov Strahil, Bastida Jaume, Tsvetkova Reneta, Viladomat Francesc, Codina Carles
Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Catalonia, Spain.
Z Naturforsch C J Biosci. 2009 May-Jun;64(5-6):311-6. doi: 10.1515/znc-2009-5-601.
Twenty-one alkaloids and related compounds were found in Sternbergia colchiciflora (Amaryllidaceae), a hitherto not studied plant species. Twenty of them were detected by GC-MS in the crude extracts of this plant species. Ten alkaloids were isolated and their structures confirmed by NMR, MS and CD measurements. Many of the compounds found in this species, such as lycorine, tazettine, haemanthidine, are known to possess strong bioactivity. Variations in the alkaloid pattern were found during the phenological cycle of the plant. Lycorine-type compounds were dominant in the plant organs during both the flowering period and dormancy. The alkaloid pattern during both periods of leaf development and fructification was dominated by haemanthamine-type in the leaves and lycorine-type compounds in the bulbs, respectively.
在迄今尚未研究过的植物物种秋水仙叶斯特恩贝格氏花（石蒜科）中发现了21种生物碱及相关化合物。其中20种通过气相色谱 - 质谱联用仪在该植物物种的粗提物中检测到。分离出10种生物碱，并通过核磁共振、质谱和圆二色光谱测量确定了它们的结构。该物种中发现的许多化合物，如石蒜碱、泰泽汀、海芒果碱，已知具有很强的生物活性。在植物的物候周期中发现了生物碱模式的变化。在开花期和休眠期，石蒜碱型化合物在植物器官中占主导地位。在叶片发育和结果实的两个时期，生物碱模式分别以海芒果胺型在叶片中占主导和石蒜碱型化合物在鳞茎中占主导。
