Department of Medical Education, Jawaharlal Nehru Medical College, Belgaum, India.
J Perinatol. 2012 Jun;32(6):431-7. doi: 10.1038/jp.2011.115. Epub 2011 Aug 18.
To determine whether consanguinity adversely influences pregnancy outcome in South India, where consanguinity is a common means of family property retention.
Data were collected from a prospective cohort of 647 consenting women, consecutively registered for antenatal care between 14 and 18 weeks gestation, in Belgaum district, Karnataka in 2005. Three-generation pedigree charts were drawn for consanguineous participants. χ (2)-Test and Student's t-test were used to assess categorical and continuous data, respectively, using SPSS version 14. Multivariate logistic regression adjusted for confounding variables.
Overall, 24.1% of 601 women with singleton births and outcome data were consanguineous. Demographic characteristics between study groups were similar. Non-consanguineous couples had fewer stillbirths (2.6 vs 6.9% P=0.017; adjusted P=0.050), miscarriages (1.8 vs 4.1%, P=0.097; adjusted P=0.052) and lower incidence of birth weight <2500 g (21.8 vs 29.5%, P=0.071, adjusted P=0.044). Gestation <37 weeks was 6.2% in both the groups. Adjusted for consanguinity and other potential confounders, age <20 years was protective of stillbirth (P=0.01), pregnancy loss (P=0.023) and preterm birth (P=0.013), whereas smoking (P=0.015) and poverty (P=0.003) were associated with higher rates of low birth weight.
Consanguinity significantly increases pregnancy loss and birth weight <2500 g.
在印度南部，血缘关系是保留家庭财产的常见方式，本研究旨在确定血缘关系是否对妊娠结局产生不利影响。
本研究数据来自于 2005 年在卡纳塔克邦贝尔高姆区进行的一项前瞻性队列研究，共纳入了 647 名 14-18 周龄连续登记接受产前检查的同意参与者。对血缘关系参与者绘制了三代系谱图。使用 SPSS 版本 14，采用 χ 2-检验和 Student's t 检验分别评估分类和连续数据。采用多变量逻辑回归调整混杂变量。
601 名单胎分娩且有结局数据的女性中，共有 24.1%为血缘关系。研究组间的人口统计学特征相似。非血缘关系夫妇的死胎率（2.6% vs. 6.9%，P=0.017；调整后 P=0.050）、流产率（1.8% vs. 4.1%，P=0.097；调整后 P=0.052）和低出生体重发生率（<2500 g，21.8% vs. 29.5%，P=0.071，调整后 P=0.044）均较低。两组的妊娠<37 周的比例均为 6.2%。在调整了血缘关系和其他潜在混杂因素后，年龄<20 岁可保护胎儿免受死产（P=0.01）、妊娠丢失（P=0.023）和早产（P=0.013），而吸烟（P=0.015）和贫困（P=0.003）与较低的出生体重发生率相关。
血缘关系显著增加妊娠丢失和低出生体重发生率。
