Rapamycin for treatment of epilepsy: antiseizure, antiepileptogenic, both, or neither?
作者信息
Wong Michael
出版信息
Epilepsy Curr. 2011 Mar;11(2):66-8. doi: 10.5698/1535-7511-11.2.66.
Abstract
摘要
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Rapamycin for treatment of epilepsy: antiseizure, antiepileptogenic, both, or neither?雷帕霉素用于治疗癫痫：抗惊厥、抗癫痫发生，还是两者兼具，抑或两者皆无？
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本文引用的文献
1
Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy.雷帕霉素抑制颞叶癫痫小鼠模型中苔藓纤维发芽，但不能抑制癫痫发作频率。
J Neurosci. 2011 Feb 9;31(6):2337-47. doi: 10.1523/JNEUROSCI.4852-10.2011.
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Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis.依维莫司治疗结节性硬化症的室管膜下巨细胞星形细胞瘤。
N Engl J Med. 2010 Nov 4;363(19):1801-11. doi: 10.1056/NEJMoa1001671.
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Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): a double-edged sword?哺乳动物雷帕霉素靶蛋白（mTOR）调控细胞死亡和癫痫发生：一把双刃剑？
Cell Cycle. 2010 Jun 15;9(12):2281-5. doi: 10.4161/cc.9.12.11866.
4
Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies.雷帕霉素靶蛋白（mTOR）抑制作为一种潜在的抗癫痫发生治疗：从结节性硬化症到常见的获得性癫痫。
Epilepsia. 2010 Jan;51(1):27-36. doi: 10.1111/j.1528-1167.2009.02341.x. Epub 2009 Oct 8.
5
Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy.抑制雷帕霉素哺乳动物靶点信号通路可抑制颞叶癫痫啮齿动物模型中齿状颗粒细胞轴突的发芽。
J Neurosci. 2009 Jun 24;29(25):8259-69. doi: 10.1523/JNEUROSCI.4179-08.2009.
6
The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy.雷帕霉素哺乳动物靶标信号通路在颞叶癫痫模型中介导癫痫发生。
J Neurosci. 2009 May 27;29(21):6964-72. doi: 10.1523/JNEUROSCI.0066-09.2009.
7
Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.雷帕霉素可抑制皮质发育异常小鼠模型中的癫痫发作和神经元肥大。
Dis Model Mech. 2009 Jul-Aug;2(7-8):389-98. doi: 10.1242/dmm.002386. Epub 2009 May 26.
8
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice.mTORC1的药理学抑制可抑制神经特异性Pten基因敲除小鼠的解剖学、细胞和行为异常。
J Neurosci. 2009 Feb 11;29(6):1773-83. doi: 10.1523/JNEUROSCI.5685-08.2009.
9
Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.结节性硬化症Tsc2+/-小鼠模型学习缺陷的逆转
Nat Med. 2008 Aug;14(8):843-8. doi: 10.1038/nm1788. Epub 2008 Jun 22.
10
Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function.结节性硬化症神经元模型对雷帕霉素哺乳动物靶点（mTOR）抑制剂的反应：对mTORC1和Akt信号传导的影响导致存活率和功能改善。
J Neurosci. 2008 May 21;28(21):5422-32. doi: 10.1523/JNEUROSCI.0955-08.2008.
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