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Polo, greatwall, and protein phosphatase PP2A Jostle for pole position.

作者信息

Boke Elvan, Hagan Iain M

机构信息

CRUK Cell Division Group, Paterson Institute for Cancer Research, Manchester, United Kingdom.

出版信息

PLoS Genet. 2011 Aug;7(8):e1002213. doi: 10.1371/journal.pgen.1002213. Epub 2011 Aug 11.

DOI:10.1371/journal.pgen.1002213
PMID:21852954
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3154949/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ba/3154949/c7fb9672690b/pgen.1002213.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ba/3154949/c7fb9672690b/pgen.1002213.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ba/3154949/c7fb9672690b/pgen.1002213.g001.jpg

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引用本文的文献

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本文引用的文献

1
PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in drosophila embryos.PP2A-twins 通过拮抗 greatwall 并与 polo 合作,促进细胞周期进程和中心体附着到果蝇胚胎的细胞核。
PLoS Genet. 2011 Aug;7(8):e1002227. doi: 10.1371/journal.pgen.1002227. Epub 2011 Aug 11.
2
Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis.抑制 scant 鉴定 Endos 为有丝分裂中 greatwall 激酶的底物和蛋白磷酸酶 2A 的负调节剂。
PLoS Genet. 2011 Aug;7(8):e1002225. doi: 10.1371/journal.pgen.1002225. Epub 2011 Aug 11.
3
Regulation of Greatwall kinase during Xenopus oocyte maturation.
沃尔夫冈激酶在爪蟾卵母细胞成熟过程中的调控作用。
Mol Biol Cell. 2011 Jul 1;22(13):2157-64. doi: 10.1091/mbc.E11-01-0008. Epub 2011 May 5.
4
The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A.长城激酶的底物 Arpp19 通过抑制蛋白磷酸酶 2A 来控制有丝分裂。
Science. 2010 Dec 17;330(6011):1673-7. doi: 10.1126/science.1197048.
5
Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis.长城激酶磷酸化了一种蛋白磷酸酶 2A 的抑制剂,这种抑制剂对于有丝分裂是必需的。
Science. 2010 Dec 17;330(6011):1670-3. doi: 10.1126/science.1195689.
6
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.活细胞成像 RNAi 筛选鉴定出 PP2A-B55alpha 和 importin-beta1 是人细胞有丝分裂退出的关键调节因子。
Nat Cell Biol. 2010 Sep;12(9):886-93. doi: 10.1038/ncb2092. Epub 2010 Aug 15.
7
Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway.TORC1 调控的 G0 程序的启动需要 Igo1/2,它通过 5'-3' mRNA 降解途径来许可特定的 mRNA 逃避降解。
Mol Cell. 2010 May 14;38(3):345-55. doi: 10.1016/j.molcel.2010.02.039.
8
The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites.M 期激酶 Greatwall(Gwl)促进了针对 CDK 磷酸化位点的磷酸酶 PP2A/B55delta 的失活。
Mol Biol Cell. 2009 Nov;20(22):4777-89. doi: 10.1091/mbc.e09-07-0643. Epub 2009 Sep 30.
9
Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts.PP2A-B55δ 的调控活性对于控制非洲爪蟾卵提取物中细胞有丝分裂的进出至关重要。
EMBO J. 2009 Sep 16;28(18):2777-85. doi: 10.1038/emboj.2009.238. Epub 2009 Aug 20.
10
Greatwall maintains mitosis through regulation of PP2A.长城通过调节蛋白磷酸酶2A维持有丝分裂。
EMBO J. 2009 Sep 16;28(18):2786-93. doi: 10.1038/emboj.2009.228. Epub 2009 Aug 13.