Zwiefel Karin, Janni Wolfgang
Frauenklinik der Heinrich-Heine-Universität Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf.
Med Monatsschr Pharm. 2011 Aug;34(8):280-88; quiz 289-90.
Breast cancer is the most frequent malignoma in female individuals: more than 10 out 100 females suffer from the disease. The understanding of breast cancer as a primarily local disease has undergone a fundamental change in the last few decades. While throughout most of the previous century breast cancer was still mainly conceived of as a predominantly local disease, the radical nature of surgery can now be reduced to a minimum by the use of breast conserving procedures and axillary sentinel lymph node excision. The systemic use of cytostatic and endocrine therapeutic modalities has simultaneously provided a major overall survival benefit for patients treated in accordance with current therapeutic standards. The multidisciplinary treatment challenge of breast cancer comprises nowadays surgery, systemic treatment and radiotherapy and aims to a more individualized therapy.
每100名女性中就有超过10人患有这种疾病。在过去几十年里,对乳腺癌作为一种主要的局部疾病的认识发生了根本性的变化。在上个世纪的大部分时间里,乳腺癌仍主要被认为是一种主要的局部疾病,而现在通过采用保乳手术和腋窝前哨淋巴结切除术,手术的根治性可以降至最低限度。同时,细胞毒性和内分泌治疗方法的全身应用为按照当前治疗标准治疗的患者带来了显著的总体生存益处。如今,乳腺癌的多学科治疗挑战包括手术、全身治疗和放疗,旨在实现更个体化的治疗。