Büsselberg Dietrich, Florea Ana-Maria
Weill Cornell Medicine in Qatar, Qatar Foundation-Education City, POB 24144 Doha, Qatar.
Institute of Neuropathology, Heinrich-Heine University Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany.
Cancers (Basel). 2017 May 9;9(5):48. doi: 10.3390/cancers9050048.
Cancer is a main public health problem all over the world. It affects millions of humans no matter their age, gender, education, or social status. Although chemotherapy is the main strategy for the treatment of cancer, a major problem limiting its success is the intrinsic or acquired drug resistance. Therefore, cancer drug resistance is a major impediment in medical oncology resulting in a failure of a successful cancer treatment. This mini-overview focuses on the interdependent relationship between intracellular calcium ([Ca]) signaling and multidrug resistance of cancer cells, acquired upon treatment of tumors with anticancer drugs. We propose that [Ca] signaling modulates gene expression of multidrug resistant (MDR) genes which in turn can be modulated by epigenetic factors which in turn leads to modified protein expression in drug resistant tumor cells. A precise knowledge of these mechanisms will help to develop new therapeutic strategies for drug resistant tumors and will improve current chemotherapy.
癌症是全球主要的公共卫生问题。无论年龄、性别、教育程度或社会地位如何，它都会影响数百万的人。尽管化疗是治疗癌症的主要策略，但限制其成功的一个主要问题是内在或获得性耐药性。因此，癌症耐药性是医学肿瘤学中的一个主要障碍，导致成功的癌症治疗失败。本综述聚焦于细胞内钙（[Ca]）信号与癌细胞多药耐药性之间的相互依存关系，这种耐药性是在用抗癌药物治疗肿瘤后获得的。我们提出，[Ca]信号调节多药耐药（MDR）基因的基因表达，而这些基因又可被表观遗传因素调节，进而导致耐药肿瘤细胞中蛋白质表达的改变。对这些机制的精确了解将有助于开发针对耐药肿瘤的新治疗策略，并改善当前的化疗方法。
