酰胺基自由基的立体选择性 6-endo 环化。实验和理论研究。
Stereoselective 6-exo cyclization of amidyl radicals. An experimental and theoretical study.
机构信息
Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PR China.
出版信息
J Org Chem. 2011 Oct 7;76(19):8100-6. doi: 10.1021/jo2014406. Epub 2011 Aug 26.
PMID:21854031
Abstract
Unsaturated primary amidyl radicals of Z-configurations underwent efficient chemo- and stereoselective 6-exo cyclization reactions via chair-conformational transition states, leading to the predominant formations of 3,6-trans, 4,6-cis, or 5,6-trans substituted δ-lactams.
摘要
Z-构型的未饱和伯酰胺基自由基通过椅式构象过渡态经历了高效的化学和立体选择性 6-endo 环化反应，主要生成 3,6-反式、4,6-顺式或 5,6-反式取代的 δ-内酰胺。
Zotero 插件