通过碘化镁促进仲亚甲基环丙基酰胺的扩环反应合成β,γ-不饱和内酰胺。
Synthesis of beta,gamma-unsaturated lactams via a magnesium iodide promoted ring expansion of secondary methylenecyclopropyl amides.
作者信息
Scott Mark E, Schwarz Christina A, Lautens Mark
机构信息
Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
出版信息
Org Lett. 2006 Nov 23;8(24):5521-4. doi: 10.1021/ol0621957.
PMID:17107062
Abstract
A novel and efficient route to exo-beta,gamma-unsaturated lactams from substituted and non-substituted secondary methylenecyclopropyl amides is reported. Subsequent modification of the resulting exo-beta,gamma-unsaturated lactams provides access to several pharmaceutically relevant scaffolds. [reaction: see text].
摘要
报道了一种从取代和未取代的仲亚甲基环丙基酰胺制备外型-β,γ-不饱和内酰胺的新颖且高效的方法。对所得外型-β,γ-不饱和内酰胺进行后续修饰可得到几种与药物相关的骨架。[反应：见正文]
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