School of Biological Sciences, Life Sciences Building 85, University of Southampton, Southampton, SO17 1BJ, UK.
Trends Biochem Sci. 2011 Sep;36(9):493-500. doi: 10.1016/j.tibs.2011.06.007. Epub 2011 Aug 18.
Are lipid interactions with membrane proteins best described in terms of the physical properties of the lipid bilayer or in terms of direct molecular interactions between particular lipid molecules and particular sites on a protein? A molecular interpretation is more challenging because it requires detailed knowledge of the 3D structure of a membrane protein, but recent studies have suggested that a molecular interpretation is necessary. Here, the idea is explored that lipid molecules modify the ways that transmembrane α-helices pack into bundles, by penetrating between the helices and by binding into clefts between the helices, and that these effects on helix packing will modulate the activity of a membrane protein.
脂质与膜蛋白的相互作用是最好用脂质双层的物理性质来描述，还是用特定脂质分子与蛋白质上特定部位之间的直接分子相互作用来描述？分子解释更具挑战性，因为它需要对膜蛋白的 3D 结构有详细的了解，但最近的研究表明，分子解释是必要的。在这里，探讨了这样一种观点，即脂质分子通过穿透螺旋之间并结合到螺旋之间的裂缝中来改变跨膜α螺旋组装成束的方式，并且这些对螺旋组装的影响将调节膜蛋白的活性。
