Department of Dermatology and Phototherapy Unit, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel.
J Am Acad Dermatol. 2012 May;66(5):761-6. doi: 10.1016/j.jaad.2011.04.017. Epub 2011 Aug 19.
Oral lichen planus (OLP) is a chronic inflammatory disease that can significantly affect the patient's quality of life.
We sought to demonstrate the therapeutic efficacy of local ultraviolet (UV) B phototherapy in OLP.
Patients with biopsy-confirmed erosive OLP recalcitrant to previous medical therapy were treated with the TheraLight UV 120-2 system (TheraLight Inc, Carlsbad, CA). Lesions were accessed directly using a flexible fiber guide. Local phototherapy was delivered 3 times a week, with gradual increase in UVB dose every other session. Affected oral mucosa was defined as the area showing erosions or symptomatic reticular lesions. Complete response was defined as reduction of at least 80% in the affected mucosal area, and partial response was defined as a reduction of 50% to 80% in the affected mucosal area. The primary end point was efficacy after 8 weeks of treatment.
Fourteen patients were included in the study. Nine achieved complete response and 5 partial response after 8 weeks. Ten patients were continued on maintenance therapy and were able to maintain their response for another 29 weeks. None of the patients showed any serious side effects from local UVB therapy.
The study was performed in a small series of patients at a single medical center. Further studies with larger patient samples are required to validate our findings.
Local UVB phototherapy may be a promising treatment modality for erosive OLP.
口腔扁平苔藓（OLP）是一种慢性炎症性疾病，可显著影响患者的生活质量。
本研究旨在展示局部紫外线（UV）B 光疗在 OLP 中的治疗效果。
对经活检证实为既往药物治疗无效的糜烂性 OLP 患者，使用 TheraLight UV 120-2 系统（TheraLight Inc，加利福尼亚州卡尔斯巴德）进行治疗。使用柔性光纤导丝直接对病变部位进行治疗。每周进行 3 次局部光疗，每次治疗时逐渐增加 UVB 剂量。受影响的口腔黏膜定义为出现糜烂或有症状的网状病变的区域。完全缓解定义为受影响的黏膜面积减少至少 80%，部分缓解定义为受影响的黏膜面积减少 50%至 80%。主要终点是治疗 8 周后的疗效。
本研究共纳入 14 例患者。9 例患者在 8 周后达到完全缓解，5 例患者达到部分缓解。10 例患者继续接受维持治疗，在接下来的 29 周内能够维持缓解。所有患者均未出现局部 UVB 治疗的严重不良反应。
本研究在单中心的小系列患者中进行，需要进一步的大样本患者研究来验证我们的发现。
局部 UVB 光疗可能是治疗糜烂性 OLP 的一种有前途的治疗方法。
