College of Basic Medicine, Yanbian University, Yanji, Jilin 133000, China.
Pharmacol Rep. 2011;63(3):834-9. doi: 10.1016/s1734-1140(11)70596-5.
The antidepressant-like effects of N-palmitoylethanolamide (PEA), a putative endocannabinoid, was investigated in mice using the tail suspension test (TST) and the forced swimming test (FST). In TST, PEA (10, 20, and 40 mg/kg) produced a statistically significant reduction in immobility (50, 32, and 34%, respectively, vs. the control group), whereas fluoxetine (20 mg/kg) reduced immobility by 38%. In FST, PEA (5, 10, and 20 mg/kg) produced a statistically significant reduction in immobility (15, 21, and 36%, respectively), whereas fluoxetine (20 mg/kg) reduced immobility by 18%. Moreover, PEA (20 mg/kg) did not significantly change motor activity in a spontaneous behavioral test. In conclusion, PEA (dose range of 5-40 mg/kg) administered orally reduced immobility in TST and FST, comparable to the antidepressant effect of fluoxetine, and had no effect on spontaneous activity in mice.
内源性大麻素 N-棕榈酰乙醇酰胺（PEA）具有抗抑郁作用，本研究旨在利用悬尾试验（TST）和强迫游泳试验（FST）观察 PEA 在小鼠体内的抗抑郁效果。在 TST 中，PEA（10、20 和 40mg/kg）可显著减少不动时间（分别减少 50%、32%和 34%，与对照组相比），而氟西汀（20mg/kg）减少不动时间 38%。在 FST 中，PEA（5、10 和 20mg/kg）可显著减少不动时间（分别减少 15%、21%和 36%），而氟西汀（20mg/kg）减少不动时间 18%。此外，PEA（20mg/kg）在自发行为试验中对运动活性无显著影响。总之，PEA（5-40mg/kg 剂量范围）口服给药可减少 TST 和 FST 中的不动时间，与氟西汀的抗抑郁作用相当，且对小鼠的自发活动无影响。
