Research in Biological Sciences-NUPEB, School of Nutrition, Ouro Preto University, Minas Gerais, Brazil.
J Biosci. 2011 Sep;36(4):731-7. doi: 10.1007/s12038-011-9097-y.
Hypertension is one of the leading causes of disability or death due to stroke, heart attack and kidney failure. Because the etiology of essential hypertension is not known and may be multifactorial, the use of experimental animal models has provided valuable information regarding many aspects of the disease, which include etiology, pathophysiology, complications and treatment. The models of hypertension are various, and in this review, we provide a brief overview of the most widely used animal models, their features and their importance.
高血压是导致残疾或死亡的主要原因之一,可由中风、心脏病和肾衰竭引起。由于原发性高血压的病因尚不清楚,可能是多因素的,因此实验动物模型的使用为该疾病的许多方面提供了有价值的信息,包括病因、病理生理学、并发症和治疗。高血压模型多种多样,在这篇综述中,我们简要概述了最广泛使用的动物模型、它们的特点及其重要性。