Sadreddini Seyyed A, Abolfathi Ali A, Khandagi Reza, Talebi Mahnaz, Lakian Attusa
Department of Neurology, Imam Hospital, Tabriz University, Tabriz, Iran. Tel/Fax. +98 (41) 13342889. E-mail:
Neurosciences (Riyadh). 2007 Jul;12(3):202-6.
To ascertain the most prevalent risk factor for stroke.
We performed a descriptive and analytical prospective study on patients with stroke admitted to the neurology wards of Imam Hospital, Tabriz, Iran during 2004 and 2005. The study comprised 100 ischemic stroke (IS) patients consisting of 46 men and 54 women with a mean age of 67 +/- 15, and 100 age and gender matched apparently healthy subjects. Plasma levels of C-Reactive protein (CRP), fibrinogen, platelet counts, lipoprotein (a) (LP (a)), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), and triglycerides (TG) were measured in both patients and controls. Background disease was also investigated in the patients. Hemorrhagic and embolic stroke patients were excluded from the study.
We found no significant difference in serum fibrinogen, HDL-c levels, and platelet counts between patients and control subjects, however, levels of LP (a), TG, LDH-c, and CRP were significantly higher in patients than controls. Among the predisposing background illnesses, the most common risk factors were hypertension and hyperlipidemia. The frequency of studied risk factors among patients was: no risk factors (20%), one risk factor (32%), 2 risk factors (36%), and 3 risk factors (12%).
Hypertension was the most prevalent background disease in IS patients. We also found that although there is close relationship in the incidence of IS with levels of LP (a), TC, TG, LDL-c, and CRP, the cutoff point frequency of fibrinogen, CRP, LP (a), and platelet counts was variable from patient to patient.
确定中风最常见的危险因素。
我们对2004年至2005年期间入住伊朗大不里士伊玛目医院神经科病房的中风患者进行了一项描述性和分析性前瞻性研究。该研究包括100例缺血性中风（IS）患者，其中46名男性和54名女性，平均年龄为67±15岁，以及100名年龄和性别匹配的明显健康的受试者。测量了患者和对照组的血浆C反应蛋白（CRP）、纤维蛋白原、血小板计数、脂蛋白（a）[LP（a）]、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）、总胆固醇（TC）和甘油三酯（TG）水平。还对患者的基础疾病进行了调查。出血性和栓塞性中风患者被排除在研究之外。
我们发现患者和对照组之间的血清纤维蛋白原、HDL-c水平和血小板计数没有显著差异，然而，患者的LP（a）、TG、LDL-c和CRP水平显著高于对照组。在诱发基础疾病中，最常见的危险因素是高血压和高脂血症。患者中所研究危险因素的频率为：无危险因素（20%）、一个危险因素（32%）、两个危险因素（36%）和三个危险因素（12%）。
高血压是IS患者中最常见的基础疾病。我们还发现，虽然IS的发病率与LP（a）、TC、TG、LDL-c和CRP水平密切相关，但纤维蛋白原、CRP、LP（a）和血小板计数的临界值频率因患者而异。
