Leschke M, Strauer B E
Medizinische Klinik und Poliklinik der Universität Düsseldorf.
Arzneimittelforschung. 1990 Mar;40(3A):356-62.
Beside the well-known risk factors for atherogenesis fibrinogen is an independent risk factor. High plasma fibrinogen levels predispose to hypercoagulability and thrombotic processes. Furthermore, rheological mechanisms, interfering with cell-to-cell contacts, and fluid-dynamic factors, facilitate local endothelial lesions resulting in atherosclerosis. Plasma fibrinogen, as the major contributing factor to plasma viscosity and red-blood-cell aggregation can limit oxygen supply and blood flow in microcirculation even in the absence of apparent coronary artery disease. Pharmacological interventions, in order to decrease elevated fibrinogen levels, do improve myocardial ischemia in patients with severe coronary artery disease.
除了众所周知的动脉粥样硬化形成风险因素外，纤维蛋白原是一个独立的风险因素。高血浆纤维蛋白原水平易导致血液高凝性和血栓形成过程。此外，影响细胞间接触的流变学机制以及流体动力学因素会促使局部内皮损伤，从而导致动脉粥样硬化。血浆纤维蛋白原作为血浆粘度和红细胞聚集的主要促成因素，即使在没有明显冠状动脉疾病的情况下，也会限制微循环中的氧气供应和血流。为降低升高的纤维蛋白原水平而进行的药物干预确实能改善严重冠状动脉疾病患者的心肌缺血状况。
