The Kirby Institute for Infection and Immunity in Society, Faculty of Medicine, University of New South Wales, Sydney, Australia.
PLoS One. 2011;6(8):e22768. doi: 10.1371/journal.pone.0022768. Epub 2011 Aug 15.
This study aims to estimate the magnitude and changing trends of HIV, syphilis and HIV-syphilis co-infections among men who have sex with men (MSM) in China during 2003-2008 through a systematic review of published literature.
METHODOLOGY/PRINCIPAL FINDINGS: Chinese and English literatures were searched for studies reporting HIV and syphilis prevalence among MSM from 2003 to 2008. The prevalence estimates were summarized and analysed by meta-analyses. Meta-regression was used to identify the potential factors that are associated with high heterogeneities in meta-analysis. Seventy-one eligible articles were selected in this review (17 in English and 54 in Chinese). Nationally, HIV prevalence among MSM increased from 1.3% during 2003-2004 to 2.4% during 2005-2006 and to 4.7% during 2007-2008. Syphilis prevalence increased from 6.8% during 2003-2004 to 10.4% during 2005-2006 and to 13.5% during 2007-2008. HIV-syphilis co-infection increased from 1.4% during 2005-2006 to 2.7% during 2007-2008. Study locations and study period are the two major contributors of heterogeneities of both HIV and syphilis prevalence among Chinese MSM.
CONCLUSIONS/SIGNIFICANCE: There have been significant increases in HIV and syphilis prevalence among MSM in China. Scale-up of HIV and syphilis screening and implementation of effective public health intervention programs should target MSM to prevent further spread of HIV and syphilis infection.
本研究旨在通过系统综述已发表文献，估计 2003-2008 年期间中国男男性行为者（MSM）中 HIV、梅毒和 HIV-梅毒合并感染的流行程度和变化趋势。
方法/主要发现：检索了 2003 年至 2008 年期间报道 MSM 中 HIV 和梅毒流行率的中、英文文献。通过荟萃分析总结和分析流行率估计值。采用Meta 回归分析确定与Meta 分析中高度异质性相关的潜在因素。本综述共纳入 71 篇合格文献（英文 17 篇，中文 54 篇）。全国范围内，MSM 中 HIV 流行率从 2003-2004 年的 1.3%上升至 2005-2006 年的 2.4%，再上升至 2007-2008 年的 4.7%。梅毒流行率从 2003-2004 年的 6.8%上升至 2005-2006 年的 10.4%，再上升至 2007-2008 年的 13.5%。HIV-梅毒合并感染率从 2005-2006 年的 1.4%上升至 2007-2008 年的 2.7%。研究地点和研究时间是造成中国 MSM 中 HIV 和梅毒流行率异质性的两个主要因素。
结论/意义：中国 MSM 中 HIV 和梅毒的流行率显著上升。扩大 HIV 和梅毒筛查，并实施有效的公共卫生干预措施，应将 MSM 作为目标人群，以防止 HIV 和梅毒感染的进一步传播。
