Al-Saadi Muslim M, Meo Sultan A, Al-Drees Abdul M, Mohamed Sarar, Shaikh Shaffi A, Al-Rubeaan Khalid
Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Saudi Med J. 2011 Aug;32(8):778-83.
To determine the lung function among Saudi type 1 diabetes mellitus (T1DM) children and adolescents.
This study was conducted in the Department of Pediatrics, Division of Pediatric Pulmonology and University Diabetes Centre, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia from December 2008 to July 2010. A group of 52 (26 male and 26 female) volunteer T1DM children were recruited with an age range from 8-14 years (mean 12.05 +/- 1.42 years), mean duration of disease of 5.25 +/- 0.47 years, and mean glycosylated hemoglobin of 11.27 +/- 0.31%. Spirometry was performed on an Electronic Spirometer (Compact Vitalograph, Stockwell, London, UK).
Pulmonary function in children with diabetes showed significant lower mean values of actual lung function parameters forced vital capacity (FVC), peak expiratory flow (PEF), and maximum mid expiratory flow rate (MMEF) compared to their predicted values. However, there was no significant reduction in the actual forced expiratory volume in the first second (FEV1), and FEV1/FVC% compared to their predicted values.
The actual lung function data among Saudi T1DM children and adolescents showed significantly lower values of FVC, PEF, and MMEF compared to the predicted lung function data.
确定沙特1型糖尿病（T1DM）儿童和青少年的肺功能。
本研究于2008年12月至2010年7月在沙特阿拉伯利雅得国王沙特大学医学院儿科、儿科肺病科和大学糖尿病中心进行。招募了一组52名（26名男性和26名女性）志愿者T1DM儿童，年龄范围为8至14岁（平均12.05 +/- 1.42岁），平均病程为5.25 +/- 0.47年，平均糖化血红蛋白为11.27 +/- 0.31%。使用电子肺活量计（紧凑型肺活量计，英国伦敦斯托克韦尔）进行肺活量测定。
与预测值相比，糖尿病儿童的肺功能显示实际肺功能参数用力肺活量（FVC）、呼气峰值流速（PEF）和最大呼气中期流速（MMEF）的平均值显著降低。然而，与预测值相比，第一秒用力呼气量（FEV1）和FEV1/FVC%的实际值没有显著降低。
与预测的肺功能数据相比，沙特T1DM儿童和青少年的实际肺功能数据显示FVC、PEF和MMEF的值显著降低。
