[T细胞共刺激。基本机制与新进展]
[T-cell costimulation. Basic mechanisms and new aspects].
作者信息
Hutloff A
机构信息
Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), Charitéplatz 1, Berlin, Germany.
出版信息
Z Rheumatol. 2011 Sep;70(7):588-91. doi: 10.1007/s00393-011-0862-y.
PMID:21858484
Abstract
Recent publications regarding the function of the T-cell costimulators CD226 and TIGIT as well as the identification of the new costimulatory ligand VISTA are of great interest for an understanding of autoimmune diseases. Both systems display striking similarities to the well-established costimulators CD28/CTLA-4 and PD-1.
摘要
最近有关T细胞共刺激分子CD226和TIGIT的功能以及新的共刺激配体VISTA的鉴定的出版物，对于理解自身免疫性疾病具有重要意义。这两个系统与已确立的共刺激分子CD28/CTLA-4和PD-1表现出惊人的相似性。
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