Mabeta Peace, Pepper Michael S
Department of Physiology, University of Pretoria, South Africa.
Int J Dev Biol. 2011;55(4-5):431-7. doi: 10.1387/ijdb.103221pm.
Hemangiomas are benign neoplasms of the vasculature frequently encountered in children. Several studies have shown that these tumors are characterized by excessive angiogenesis. Although benign, the lesions can present with complications, and may thus require treatment. There are multiple therapeutic options available for patients with problematic or life threatening hemangiomas, some of which have serious side effects. Randomized clinical trials and evidence-based studies on the efficacy of these treatments is still lacking. The recognition that excessive angiogenesis underlies hemangiogenesis offers an opportunity for the development of safer therapeutic strategies that are based on the inhibition of angiogenesis. We review medical therapies currently employed in the management of hemangiomas and the role of angiogenesis inhibition in hemangioma therapy.
血管瘤是儿童中常见的血管良性肿瘤。多项研究表明，这些肿瘤的特征是血管生成过多。虽然是良性的，但这些病变可能会出现并发症，因此可能需要治疗。对于有问题的或危及生命的血管瘤患者，有多种治疗选择，其中一些有严重的副作用。目前仍缺乏关于这些治疗方法疗效的随机临床试验和循证研究。认识到血管生成过多是血管瘤发生的基础，为开发基于抑制血管生成的更安全治疗策略提供了机会。我们综述了目前用于治疗血管瘤的医学疗法以及血管生成抑制在血管瘤治疗中的作用。
