使用 1H NMR 光谱测量重原子同位素效应。
Measurements of heavy-atom isotope effects using 1H NMR spectroscopy.
机构信息
Institute of Applied Radiation Chemistry, Faculty of Chemistry, Technical University of Lodz, Zeromskiego 116, 90-924 Lodz, Poland.
出版信息
J Org Chem. 2011 Oct 7;76(19):8033-5. doi: 10.1021/jo201226g. Epub 2011 Aug 31.
PMID:21859124
Abstract
A novel method for measuring heavy-atom KIEs for magnetically active isotopes using (1)H NMR is presented. It takes advantage of the resonance split of the protons coupled with the heavy atom in the (1)H spectrum. The method is validated by the example of the (13)C-KIE on the hydroamination of styrene with aniline, catalyzed by phosphine-ligated palladium triflates.
摘要
本文提出了一种利用（1）H NMR 测量磁活性同位素重原子 KIE 的新方法。它利用了与（1）H 谱中重原子耦合的质子的共振分裂。该方法通过膦配钯三氟甲磺酸催化苯乙烯与苯胺的氢胺化的（13）C-KIE 实例得到了验证。
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