Western University of Health Sciences, College of Osteopathic Medicine of the Pacific, Pomona, California, USA.
Surg Infect (Larchmt). 2011 Aug;12(4):317-20. doi: 10.1089/sur.2009.070.
Over the past decade, there has been an increase in both community-acquired and health-care-associated Clostridium difficile colitis secondary to broad-spectrum antibiotic exposure. Toxic megacolon is a rare complication of pseudomembranous colitis that often necessitates emergency colectomy.
Review of the pertinent English-language literature.
We present a case of community-acquired C. difficile colitis that made its initial presentation as fulminant toxic megacolon. Six months after a total colectomy, the patient has no complaints.
Prompt total colectomy may improve survival in patients with toxic megacolon. The incidence of C. difficile-related toxic megacolon and post-operative outcomes of total colectomy should be investigated in a larger observational study.
在过去的十年中，由于广谱抗生素的广泛使用，社区获得性和与医疗保健相关的艰难梭菌结肠炎的发病率有所增加。中毒性巨结肠是假膜性结肠炎的一种罕见并发症，常需要紧急结肠切除术。
对相关的英文文献进行回顾。
我们报告了一例社区获得性艰难梭菌结肠炎，其最初表现为暴发性中毒性巨结肠。全结肠切除术后 6 个月，患者无任何不适。
及时行全结肠切除术可能会提高中毒性巨结肠患者的生存率。在更大规模的观察性研究中应调查艰难梭菌相关性中毒性巨结肠的发生率和全结肠切除术后的结果。
