Briese V, Than G N, Szabo D G, Szilagyi A, Strache R R, Heinke P, Hopp H, Büttner H H
Central Institute of Diabetes, Gerhardt Katsch, Karlsburg/GDR.
Exp Clin Endocrinol. 1990 Feb;95(1):105-9. doi: 10.1055/s-0029-1210941.
Placental protein 12 (PP 12) is a soluble tissue antigen. Immunohistochemical studies have localized PP 12 in the placental syncytiotrophoblast, chorion and amnion, and also in the decidua. During normal pregnancy serum-PP 12 is already raised in the first trimester, there is then a peak at 18 weeks, a gradual fall until 32 weeks, and a moderate increase thereafter. The mean of the healthy control group at 18 weeks of pregnancy was 122.9 +/- 47.5 micrograms/l. The mean of the diabetic group with retinopathy at the same time was 192.2 +/- 78.8 micrograms/l. There was no significant difference between background retinopathy and the proliferative form of diabetic retinopathy. At all times during pregnancy the median values of PP 12 in diabetic pregnancies were significantly (p less than 0.01) above the control values. Increased PP 12 levels in diabetic pregnancy complicated by retinopathy are probably caused by decidual, placental and amniotic leakages.
胎盘蛋白12（PP 12）是一种可溶性组织抗原。免疫组织化学研究已将PP 12定位在胎盘合体滋养层、绒毛膜和羊膜，以及蜕膜中。在正常妊娠期间，血清PP 12在孕早期就已升高，然后在18周时达到峰值，直到32周逐渐下降，此后适度增加。妊娠18周时健康对照组的平均值为122.9±47.5微克/升。同时患有视网膜病变的糖尿病组的平均值为192.2±78.8微克/升。背景性视网膜病变与增殖性糖尿病视网膜病变之间无显著差异。在妊娠期间的所有时间，糖尿病妊娠中PP 12的中位数均显著高于对照组（p<0.01）。糖尿病妊娠并发视网膜病变时PP 12水平升高可能是由蜕膜、胎盘和羊膜渗漏引起的。
