Fischer U, Fritze K, Freyse E J
Central Institute of Diabetes Gerhardt Katsch, Karlsburg, GDR.
Exp Clin Endocrinol. 1990 Feb;95(1):11-21. doi: 10.1055/s-0029-1210929.
To quantitate the degree of glycemic control in relation to insulin doses required on the peritoneal route of administration, insulin dependent diabetic dogs instrumented with chronic peritoneal and venous catheters and with access devices for serial peritoneal injections, were treated with regular insulin at random order as follows: (1) subcutaneous injections, (2) peritoneal injections, (3) continuous intravenous infusion, (4) continuous peritoneal infusion. Metabolic profiles were taken over 24 h after an average duration of treatment of 2 weeks and were compared to data obtained in nondiabetic animals. Insulin doses and postprandial increase in peripheral insulinemia were higher and glycemic control was worse on peritoneal vs. subcutaneous injection therapy. Glycemic control and insulin doses were identical between peritoneal and intravenous infusion regimes. Hyperinsulinemia was only seen during nighttime in intravenously infused animals. It is concluded that in accordance with the fast pharmacokinetics of peritoneally administered insulin, sufficient glycemic and insulinemic control can only be obtained on the peritoneal route, when the insulin is applied by means of pumps.
为了定量评估与腹膜给药途径所需胰岛素剂量相关的血糖控制程度，对植入慢性腹膜和静脉导管以及用于连续腹膜注射的接入装置的胰岛素依赖型糖尿病犬，按随机顺序给予常规胰岛素，具体如下：（1）皮下注射，（2）腹膜注射，（3）持续静脉输注，（4）持续腹膜输注。在平均治疗2周后，记录24小时的代谢情况，并与非糖尿病动物的数据进行比较。与皮下注射治疗相比，腹膜注射治疗时胰岛素剂量和餐后外周胰岛素血症升高幅度更大，血糖控制更差。腹膜输注和静脉输注方案的血糖控制和胰岛素剂量相同。高胰岛素血症仅在静脉输注动物的夜间出现。得出的结论是：根据腹膜给药胰岛素的快速药代动力学，只有通过泵给药胰岛素，才能在腹膜途径上实现足够的血糖和胰岛素水平控制。
