Soret J, Vellard M, Viegas-Pequignot E, Apiou F, Dutrillaux B, Perbal B
Laboratoire d'Oncologie Virale et Moléculaire, Centre Universitaire, Orsay, France.
FEBS Lett. 1990 Apr 24;263(2):254-60. doi: 10.1016/0014-5793(90)81387-4.
In the course of our studies concerning the tissue-specific expression of the c-myb proto-oncogene, we have established the nucleotide sequence of the chicken c-myb 3'-proximal coding exons. In situ hybridization performed with different genomic DNA probes corresponding to nearly all the c-myb gene allowed us to localize the corresponding locus on the large acrocentric chromosome 3 in chicken. Our sequencing data also indicate that the 3'-proximal noncoding sequences represented in c-myb mRNA species are derived from non-contiguous exons.
在我们关于c-myb原癌基因组织特异性表达的研究过程中，我们确定了鸡c-myb 3'近端编码外显子的核苷酸序列。用几乎对应于整个c-myb基因的不同基因组DNA探针进行的原位杂交，使我们能够在鸡的大型近端着丝粒染色体3上定位相应的基因座。我们的测序数据还表明，c-myb mRNA种类中代表的3'近端非编码序列来自不连续的外显子。
