胰腺同步上皮性和神经内分泌癌：一种罕见病例系列。

Synchronous epithelial and neuroendocrine cancers of the pancreas: case series of a rare occurrence.

机构信息

Department of Medicine, Gastrointestinal Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

出版信息

Clin Colorectal Cancer. 2011 Jun;10(2):146-50. doi: 10.1016/j.clcc.2011.03.013. Epub 2011 Apr 27.

DOI:10.1016/j.clcc.2011.03.013

Abstract

The presence of neuroendocrine cells in adenocarcinomas is not an unusual finding and is well described in gastrointestinal tract cancers, eg, colorectal cancer and gastric cancer. Genetic analysis of such tumors has suggested a common multipotent progenitor stem cell origin. The prognostic significance of neuroendocrine cells in adenocarcinoma cells is unclear. There is a scant literature on synchronous pancreas ductal adenocarcinoma and pancreas neuroendocrine tumors. We report 2 cases with a purpose of discussing management strategies, prognosis, and potential etiologies of this rare presentation.

摘要

神经内分泌细胞在腺癌中的存在并不罕见，在胃肠道癌中已有很好的描述，例如结直肠癌和胃癌。此类肿瘤的基因分析表明存在共同的多能祖细胞起源。神经内分泌细胞在腺癌中的预后意义尚不清楚。关于同时发生的胰腺导管腺癌和胰腺神经内分泌肿瘤的文献很少。我们报告 2 例病例，旨在讨论这种罕见表现的治疗策略、预后和潜在病因。