Kaneko N, Kawagoe S, Hiroi M
Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Japan.
Gynecol Obstet Invest. 1990;29(2):81-7. doi: 10.1159/000293307.
A 30-year-old Japanese female with Turner's syndrome had become pregnant and delivered a normal male infant by cesarean section. Her menarche was at age 14, and secondary sex characteristics developed normally. She had some features of Turner's syndrome, and cytogenetic studies from peripheral blood lymphocytes and several tissues revealed only 45,XO karyotype without evidence of mosaicism. To our knowledge, she is only the thirteenth case of monosomy X to achieve pregnancy. A review of the literature indicates a high incidence of fetal wastage and increased chromosomal errors in the offspring of women with a 45,XO cell line with or without mosaicism.
一名患有特纳综合征的30岁日本女性怀孕并通过剖宫产分娩出一名正常男婴。她14岁初潮，第二性征发育正常。她具有一些特纳综合征的特征，外周血淋巴细胞和多个组织的细胞遗传学研究仅显示45,XO核型，无嵌合体证据。据我们所知，她是第13例单体X妊娠成功的病例。文献综述表明，有或无嵌合体的45,XO细胞系女性的后代中，胎儿流产发生率高且染色体错误增加。
