Department of Molecular and Medical Genetics, Program in Neuroscience, University of Toronto, Toronto, Canada.
J Alzheimers Dis. 2011;27(3):477-82. doi: 10.3233/JAD-2011-110650.
Alzheimer's disease (AD) is multi-factorial mental disorder characterized by a copious array of congruent features cumulating in disrupted memory and dysthymia. Though the mechanism remains elusive, the highly unspecific pharmaceutical, memantine, provides modest benefits for patients with moderate-to-severe AD. A greater understanding of how memantine affects cognitive function promises to facilitate the search for better therapeutics. We therefore examined cognitive flexibility of mice following 5 and 10 mg/kg memantine administration using a platform re-location water maze. Strikingly, subjects receiving memantine demonstrated memory impairment relative to controls when re-trained off drug, revealing a novel and unusual disruption of cognitive flexibility.
阿尔茨海默病（AD）是一种多因素的精神障碍，其特征是大量一致的特征累积，导致记忆和情绪紊乱。尽管其机制仍不清楚，但高度非特异性的药物美金刚为中重度 AD 患者提供了适度的益处。对美金刚如何影响认知功能的进一步了解有望促进更好的治疗方法的研究。因此，我们使用平台重定位水迷宫检查了 5 和 10mg/kg 美金刚给药后小鼠的认知灵活性。惊人的是，与对照组相比，接受美金刚治疗的小鼠在停药后重新训练时表现出记忆障碍，这揭示了一种新颖而异常的认知灵活性破坏。
