尼日利亚东南部阿南布拉州显性糖尿病肾病成年糖尿病患者血脂异常的患病率
Prevalence of dyslipidemia among adult diabetic patients with overt diabetic nephropathy in Anambra state south-east Nigeria.
作者信息
Jisieike-Onuigbo N N, Unuigbe E I, Kalu O A, Oguejiofor C O, Onuigbo P C
机构信息
Department of Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
出版信息
Niger J Clin Pract. 2011 Apr-Jun;14(2):171-5. doi: 10.4103/1119-3077.84009.
BACKGROUND
Dyslipidemia has been identified as a risk factor for the development and progression of diabetic renal disease.
OBJECTIVE
This study was done to determine the prevalence of dyslipidemia among diabetic patients with overt nephropathy.
MATERIALS AND METHODS
A total of 72 diabetic patients with overt diabetic nephropathy and 36 age- and sex-matched normoalbuminuric diabetic patients were studied. Their fasting lipid profile, fasting blood sugar, and renal function tests were evaluated.
RESULTS
Total serum cholesterol and serum triglycerides were significantly higher in patients with overt diabetic nephropathy compared to the controls; 66.7% and 62.5% versus 36.1% and 30.6%, respectively ( P = 0.003 and 0.002, respectively).
CONCLUSIONS
Diabetic patients with overt diabetic nephropathy have significant dyslipidemia and aggressive lipid lowering in these patients may retard their progression to end-stage renal disease.
背景
血脂异常已被确定为糖尿病肾病发生和进展的一个危险因素。
目的
本研究旨在确定显性肾病糖尿病患者中血脂异常的患病率。
材料与方法
共研究了72例显性糖尿病肾病患者以及36例年龄和性别匹配的正常白蛋白尿糖尿病患者。评估了他们的空腹血脂谱、空腹血糖和肾功能测试。
结果
与对照组相比，显性糖尿病肾病患者的总血清胆固醇和血清甘油三酯显著更高；分别为66.7%和62.5%，而对照组分别为36.1%和30.6%（P值分别为0.003和0.002）。
结论
显性糖尿病肾病患者存在显著的血脂异常，积极降低这些患者的血脂水平可能会延缓其进展至终末期肾病。
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