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Disappearing colorectal liver metastases after chemotherapy: should we be concerned?化疗后结直肠肝转移灶消失:我们是否应该担心?
J Gastrointest Surg. 2010 Nov;14(11):1691-700. doi: 10.1007/s11605-010-1348-y. Epub 2010 Sep 14.
2
Pathological response grade of colorectal liver metastases treated with neoadjuvant chemotherapy.结直肠肝转移新辅助化疗的病理反应分级。
HPB (Oxford). 2010 May;12(4):277-84. doi: 10.1111/j.1477-2574.2010.00170.x.
3
Extended preoperative chemotherapy does not improve pathologic response and increases postoperative liver insufficiency after hepatic resection for colorectal liver metastases.对于结直肠癌肝转移患者,术前延长化疗并不能改善病理反应,反而会增加肝切除术后的肝功能不全发生率。
Ann Surg Oncol. 2010 Nov;17(11):2870-6. doi: 10.1245/s10434-010-1166-1. Epub 2010 Jun 22.
4
Importance of complete pathologic response to prehepatectomy chemotherapy in treating colorectal cancer metastases.术前化疗完全病理缓解对结直肠癌肝转移治疗的重要性。
Ann Surg. 2009 Dec;250(6):935-42. doi: 10.1097/sla.0b013e3181b0c6e4.
5
Association of computed tomography morphologic criteria with pathologic response and survival in patients treated with bevacizumab for colorectal liver metastases.贝伐单抗治疗结直肠癌肝转移患者的计算机断层扫描形态学标准与病理反应及生存的相关性
JAMA. 2009 Dec 2;302(21):2338-44. doi: 10.1001/jama.2009.1755.
6
Complete pathological response in a patient with multiple liver metastases from colon cancer treated with Folfox-6 chemotherapy plus bevacizumab: a case report.结肠癌伴多发肝转移患者经 Folfox-6 化疗联合贝伐珠单抗治疗后达到完全病理缓解:1 例报告
J Hematol Oncol. 2009 Aug 6;2:35. doi: 10.1186/1756-8722-2-35.
7
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).实体瘤新的疗效评价标准:修订的RECIST指南(第1.1版)
Eur J Cancer. 2009 Jan;45(2):228-47. doi: 10.1016/j.ejca.2008.10.026.
8
Preoperative chemotherapy does not increase morbidity or mortality of hepatic resection for colorectal cancer metastases.术前化疗不会增加结直肠癌肝转移灶切除手术的发病率或死亡率。
Ann Surg Oncol. 2009 Jan;16(1):35-41. doi: 10.1245/s10434-008-0190-x. Epub 2008 Nov 6.
9
Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases.术前化疗的病理反应:肝结直肠癌转移灶切除术后的一个新结局终点
J Clin Oncol. 2008 Nov 20;26(33):5344-51. doi: 10.1200/JCO.2008.17.5299. Epub 2008 Oct 20.
10
Complete pathologic response after preoperative chemotherapy for colorectal liver metastases: myth or reality?结直肠癌肝转移术前化疗后的完全病理缓解:神话还是现实?
J Clin Oncol. 2008 Apr 1;26(10):1635-41. doi: 10.1200/JCO.2007.13.7471.

化疗后肝转移完全临床缓解:是否需要切除?

Complete clinical response of liver metastasis after chemotherapy: To resect or not?

机构信息

Jose M Ramia-Angel, Roberto De la Plaza, Jose E Quiñones, HPB Surgical Unit, Department of Surgery, Universitary Hospital of Guadalajara, Guadalajara 19002, Spain.

出版信息

World J Gastrointest Oncol. 2011 Jul 15;3(7):107-10. doi: 10.4251/wjgo.v3.i7.107.

DOI:10.4251/wjgo.v3.i7.107
PMID:21860686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3158860/
Abstract

This paper aims to update the therapeutical strategies in liver metastasis with complete clinical response (CCR) after chemotherapy and to determine if surgery is always necessary after CCR. The aim of chemotherapy is to achieve a good clinical response rather than CCR of liver metastasis. The CCR of liver metastasis after chemotherapy cannot be considered synonymous with a cure. The resection of the hepatic segment where there was hepatic metastases with CCR after chemotherapy theoretically prevents recurrence, improves survival and makes it possible to confirm whether there has been a complete pathological response. However, the medical literature about this topic is scarce and sometimes contradictory.

摘要

这篇论文旨在更新化疗后完全临床缓解(CCR)的肝转移治疗策略,并确定 CCR 后是否总是需要手术。化疗的目的是获得良好的临床反应,而不是肝转移的 CCR。化疗后肝转移的 CCR不能被认为等同于治愈。化疗后 CCR 的肝转移切除理论上可以预防复发,提高生存率,并可以确认是否存在完全的病理反应。然而,关于这个主题的医学文献很少,有时甚至相互矛盾。