自然杀伤细胞激活的机制：CD4(+) T 细胞登场。
Mechanisms of NK cell activation: CD4(+) T cells enter the scene.
机构信息
Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Université de Nice-Sophia Antipolis, UMR6097, 660, route des Lucioles, 06560 Valbonne, France.
出版信息
Cell Mol Life Sci. 2011 Nov;68(21):3457-67. doi: 10.1007/s00018-011-0796-1. Epub 2011 Aug 23.
Abstract
Natural killer (NK) cells are innate lymphocytes involved in immunosurveillance through their cytotoxic activity and their capacity to secrete inflammatory cytokines. NK cell activation is necessary to initiate effector functions and results from a complex series of molecular and cellular events. We review here the signals that trigger NK cells and discuss recent findings showing that, besides antigen-presenting cells, T cells can play a central role in the initiation of NK cell activation in lymph nodes.
摘要
自然杀伤 (NK) 细胞是先天淋巴细胞，通过其细胞毒性活性和分泌炎症细胞因子的能力参与免疫监视。NK 细胞的激活对于启动效应功能是必要的，并且源自一系列复杂的分子和细胞事件。我们在这里回顾了触发 NK 细胞的信号，并讨论了最近的发现，表明除了抗原呈递细胞外，T 细胞在淋巴结中 NK 细胞激活的起始中可以发挥核心作用。
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