Ping Zhiguang, Liu Li, Guo Xiong
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Wei Sheng Yan Jiu. 2011 Jul;40(4):472-3, 477.
To explore the interaction of plasma selenium levels and D12S304 gene site in the pathogenesis of Kashin-Beck disease (KBD).
Case-control design was taken to compare the difference of plasma selenium levels and genotype of D12S304 between KBD patients and non-patients, and the interactions were analyzed by MDR software.
Plasma selenium levels was lower in the case group than in the control group, while the D12S304 gene site was not different between the two groups, and no interaction between plasma selenium and genotype was observed.
There was no interaction between plasma selenium and genotype at D12S304. Enlarging sample size or selecting another gene site might be needed in exploring the gene-environment interactions in the pathogenesis of KBD.
探讨血浆硒水平与D12S304基因位点在大骨节病（KBD）发病机制中的相互作用。
采用病例对照设计，比较大骨节病患者与非患者血浆硒水平及D12S304基因型的差异，并通过MDR软件分析相互作用。
病例组血浆硒水平低于对照组，而两组间D12S304基因位点无差异，未观察到血浆硒与基因型之间的相互作用。
血浆硒与D12S304基因型之间不存在相互作用。在探索大骨节病发病机制中的基因-环境相互作用时，可能需要扩大样本量或选择其他基因位点。
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