State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, People's Republic of China.
Can J Microbiol. 2011 Sep;57(9):759-64. doi: 10.1139/w11-061. Epub 2011 Aug 23.
The core nucleocapsid protein VP15 of White spot syndrome virus (WSSV) was shown to interact with DNA and predicted to be involved in the packaging of the WSSV genome. In the present study, we explored the colocalization of VP15 with several nuclear proteins in insect cells. The results showed that the VP15 completely colocalized with nucleolin and fibrillarin, suggesting that VP15 is a nucleolar localization protein and plays an important role in the life cycle of WSSV in host cells.
白斑综合征病毒（WSSV）的核心核衣壳蛋白 VP15 已被证明与 DNA 相互作用，并预测其参与了 WSSV 基因组的包装。在本研究中，我们探讨了 VP15 与昆虫细胞中几种核蛋白的共定位。结果表明，VP15 与核仁蛋白核仁素和核仁小纤维蛋白完全共定位，提示 VP15 是一种核仁定位蛋白，在宿主细胞中 WSSV 的生命周期中发挥重要作用。
