Institut für Zellbiologie und Immunologie, Universität Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.
Curr Opin Biotechnol. 2011 Dec;22(6):868-76. doi: 10.1016/j.copbio.2011.06.012. Epub 2011 Aug 20.
With a growing number of protein therapeutics being developed, many of them exhibiting a short plasma half-life, half-life extension strategies find increasing attention by the biotech and pharmaceutical industry. Extension of the half-life can help to reduce the number of applications and to lower doses, thus are beneficial for therapeutic but also economic reasons. Here, a comprehensive overview of currently developed half-life extension strategies is provided including those aiming at increasing the hydrodynamic volume of a protein drug but also those implementing recycling processes mediated by the neonatal Fc receptor.
随着越来越多的蛋白质治疗药物被开发出来，其中许多药物的血浆半衰期都很短，因此延长半衰期的策略越来越受到生物技术和制药行业的关注。延长半衰期可以帮助减少应用次数和降低剂量，从而对治疗和经济都有益处。本文提供了目前开发的延长半衰期策略的全面概述，包括旨在增加蛋白质药物流体力学体积的策略，以及通过新生儿 Fc 受体介导的回收过程的策略。
