Drinka Eva K, Bargaje Archana, Erşahin Çağatay H, Patel Priya, Salhadar Alia, Sinacore James, Rajan Prabha
Department of Pathology, Loyola University Medical Center, Building 110, 2160 S. First Avenue, Maywood, IL 60153, USA.
Int J Surg Pathol. 2012 Feb;20(1):54-8. doi: 10.1177/1066896911418643. Epub 2011 Aug 23.
Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion that can present as a palpable nodule or as an incidental finding in breast biopsies.
The study comprised 79 cases diagnosed at Loyola University Medical Center from 2002 to 2009. The pathology slides were reviewed to document the distribution, type, and association with preneoplastic or neoplastic epithelial lesions. Z-test for independent proportions is used for analysis.
A total of 76 patients were female and 3 were male. In all, 59.8% of patients presented with a breast mass and in 40.2% the lesion was an incidental finding. Classical PASH morphology was seen in 97.6% and proliferative PASH in 2.4%. Associated epithelial lesions were benign proliferative changes in 60.4%, atypical ductal and atypical lobular hyperplasia in 25.6% and infiltrating carcinoma in 11% of cases.
Based on these results, extensive sampling of biopsy specimen with PASH and appropriate clinical and radiologic follow-up is recommended.
乳腺假血管瘤样间质增生（PASH）是一种良性病变，可表现为可触及的结节，或在乳腺活检时偶然发现。
该研究纳入了2002年至2009年在洛约拉大学医学中心诊断的79例病例。回顾病理切片以记录其分布、类型以及与癌前或肿瘤性上皮病变的关联。采用独立比例的Z检验进行分析。
共有76例女性患者和3例男性患者。总体而言，59.8%的患者表现为乳腺肿块，40.2%的病变是偶然发现。97.6%可见经典PASH形态，2.4%为增殖性PASH。60.4%的病例中相关上皮病变为良性增殖性改变，25.6%为非典型导管和非典型小叶增生，11%为浸润性癌。
基于这些结果，建议对PASH活检标本进行广泛取材，并进行适当的临床和影像学随访。
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