Department of Pathology, Dartmouth Hitchcock Medical Center and The Children's Hospital at Dartmouth, Lebanon, NH 03756, USA.
J Pediatr Surg. 2011 Aug;46(8):e27-31. doi: 10.1016/j.jpedsurg.2011.04.063.
Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion, characterized by a dense proliferation of stromal mesenchymal cells of myofibroblastic origin forming empty, slitlike channels. The development of PASH is subject to hormonal influence and is most commonly seen in premenopausal women. In adolescent patients, PASH is rarely reported. Here we report a case of PASH presenting in a 10-year-old girl. After the presentation and inconclusive radiographic findings, incisional biopsy revealed a soft nodule with histopathologic features characteristic of PASH. Immunoperoxidase studies showed positive immunoreactivity for CD34 and bcl-2 and negative immunoreactivity for CD31 and desmin, supporting the diagnosis of PASH. Because of the benign nature of the lesion, excisional biopsy was deferred to minimize damage to the patient's developing breast. To our knowledge, this case represents the youngest female patient with unequivocal PASH in reported literature.
乳腺假血管瘤样间质增生（PASH）是一种良性病变，其特征是由起源于肌纤维母细胞的间质间叶细胞密集增生，形成空的、裂隙状的管腔。PASH 的发生受激素影响，最常见于绝经前妇女。在青少年患者中，PASH 很少见报道。本文报告了一例 10 岁女孩发生的 PASH。临床表现和非特异性影像学检查结果后，切开活检显示一个软组织结节，具有 PASH 的组织病理学特征。免疫过氧化物酶研究显示 CD34 和 bcl-2 阳性免疫反应，CD31 和 desmin 阴性免疫反应，支持 PASH 的诊断。由于病变的良性性质，推迟了切除活检以尽量减少对患者发育中乳房的损害。据我们所知，该病例是文献报道中最年轻的女性明确的 PASH 患者。
