Moniruzzaman M, Mohiuddin T
Union Health Sub-centre, Barakpur, Khulna, Bangladesh.
Bratisl Lek Listy. 2011;112(8):472-4.
The umbilical tumor as a presenting symptom must be investigated for the possibility of metastasis. In this case, it was unlikely, as there was no primary carcinoma found elsewhere. Primary peritoneal carcinoma (also termed serous surface papillary carcinoma) is a malignancy that arises primarily from peritoneal cells. The mesothelium of the peritoneum and the germinal epithelium of the ovary arise from the same embryological origin. Although primary peritoneal carcinoma has a very poor prognosis, our patient had a disease-free interval of two years post surgery. Clinically, primary peritoneal carcinoma may be difficult to distinguish from ovarian carcinoma. Compared to ovarian carcinoma, primary peritoneal carcinoma has a higher rate of abdominal distension, volume of ascites, malignant cells in the ascitic fluid, lower rate of pelvic palpable mass, and personal breast cancer history. However, primary ovarian cancer can be excluded in this case, based on both ovaries being of normal size with no tumor involvement and a histology that favors serous carcinoma. The disease is normally disseminated throughout the peritoneum. Our patient's disease was confined to the umbilicus with no evidence of dissemination. We report a rare case of adenocarcinoma confined to the umbilicus of a 64-year-old menopausal woman presented with an umbilical lump of nine years. After five years, she presented with a 6-cm irregular periumbilical mass. She agreed to undergo an excision biopsy of the mass with total abdominal hysterectomy and bilateral salpingo-oopherectomy with omentectomy. The excision biopsy showed adenocarcinoma with an appearance suggestive of metastasis from an ovarian cystadenocarcinoma. The frozen section of the tumor showed a papillary adenocarcinoma. Histology showed adenocarcinoma favoring serous cancer. It was found that tumor markers of ovarian malignancy were normal. There was no tumor seen in the ovaries, uterus and omentum. On follow-up, there was no disease recurrence. The patient has been disease-free for two years post surgery (Fig. 5, Ref. 10).
以脐部肿物为首发症状时,必须对其转移的可能性进行评估。在本病例中,由于未在其他部位发现原发性癌,因此转移的可能性不大。原发性腹膜癌(也称为浆液性表面乳头状癌)是一种主要起源于腹膜细胞的恶性肿瘤。腹膜的间皮和卵巢的生发上皮起源于相同的胚胎学来源。尽管原发性腹膜癌的预后很差,但我们的患者术后有两年的无病生存期。临床上,原发性腹膜癌可能难以与卵巢癌区分开来。与卵巢癌相比,原发性腹膜癌腹胀、腹水体积、腹水中恶性细胞的发生率更高,盆腔可触及肿块的发生率更低,且有个人乳腺癌病史。然而,根据双侧卵巢大小正常且无肿瘤累及以及组织学表现支持浆液性癌,可排除原发性卵巢癌。该疾病通常在整个腹膜内播散。我们患者的疾病局限于脐部,无播散证据。我们报告了一例罕见的腺癌病例,该病例发生在一名64岁绝经后女性的脐部,患者出现脐部肿物9年。5年后,她出现了一个6厘米的脐周不规则肿块。她同意接受肿块切除活检,并进行全腹子宫切除术、双侧输卵管卵巢切除术和大网膜切除术。切除活检显示为腺癌,外观提示为卵巢囊腺癌转移。肿瘤的冰冻切片显示为乳头状腺癌。组织学显示腺癌支持浆液性癌。发现卵巢恶性肿瘤的肿瘤标志物正常。在卵巢、子宫和大网膜中未发现肿瘤。随访时,无疾病复发。患者术后两年无病生存(图5,参考文献10)。