Woodman D D, Hinton J W
Biol Psychol. 1978 Sep;7(1-2):103-8. doi: 10.1016/0301-0511(78)90043-1.
It is now well established that the metabolic sequeale of catecholamine secretion are mediated via cyclic nucleotides. Recent studies have indicated changes in the pattern of catecholamine secretion correlating with convictions for violence in maximum security hospital detainees. This study of the excretion rate of urinary cyclic AMP in this group of patients failed to show a correlation between adrenaline or noradrenaline and cyclic AMP secretion. However, subjects convicted of sexual offences showed a significantly greater cyclic AMP excretion than other patients and normal controls. These results are discussed in terms of the possible modification of receptor sensitivity and influence of alternative agonists such as testosterone.
现已充分证实，儿茶酚胺分泌的代谢后遗症是通过环核苷酸介导的。最近的研究表明，儿茶酚胺分泌模式的变化与最高安全级别的医院被拘留者的暴力犯罪定罪相关。对这组患者尿中环磷酸腺苷排泄率的研究未能显示肾上腺素或去甲肾上腺素与环磷酸腺苷分泌之间的相关性。然而，被判性犯罪的受试者的环磷酸腺苷排泄量明显高于其他患者和正常对照组。根据受体敏感性的可能改变以及睾酮等替代激动剂的影响对这些结果进行了讨论。
