Department of Dermatology, UMDNJ-New Jersey Medical School, Newark, New Jersey, USA.
Stem Cells Dev. 2012 Feb 10;21(3):352-62. doi: 10.1089/scd.2011.0404. Epub 2011 Oct 18.
Mesenchymal stems cells (MSCs) are a population of multipotent cells residing in several readily available adult tissue compartments, thus allowing for their ex vivo expansion. To date, therapeutic applications of MSCs have focused on their ability to hone to and support the repair of damaged tissues. More recent evidence suggests that MSCs possess low immunogenicity and a diverse array of immunosuppressive properties. In thisarticle, we will review the basic biology of bone marrow-derived MSCs including their immunoregulatory effects and the putative mechanisms underlying them. We will then present some of the recent clinical applications of MSCs that have leveraged these effects for the treatment of immune-mediated dermatoses such as graft-versus-host disease and systemic lupus erythematosus. Although MSCs offer great therapeutic promise, we will also highlight a number of pertinent challenges that should be overcome before their successful clinical translation.
间充质干细胞（MSCs）是一类存在于多种易于获得的成人组织隔室中的多能细胞，因此能够进行体外扩增。迄今为止，MSCs 的治疗应用主要集中在它们能够向受损组织归巢并支持其修复的能力上。最近的证据表明，MSCs 具有低免疫原性和多种多样的免疫抑制特性。在本文中，我们将回顾骨髓来源的 MSCs 的基本生物学特性，包括其免疫调节作用及其潜在机制。然后，我们将介绍 MSCs 的一些最近的临床应用，这些应用利用了这些作用来治疗免疫介导的皮肤病，如移植物抗宿主病和系统性红斑狼疮。尽管 MSCs 具有巨大的治疗潜力，但我们也将强调在其成功的临床转化之前，需要克服许多相关的挑战。
