School of Medicine, Xi'an Jiaotong University, No. 76, Yanta West Road, 710061, Xi'an, Shaanxi Province, P.R. China.
Curr Med Chem. 2011;18(29):4538-56. doi: 10.2174/092986711797287584.
5-Fluorouracil (5-FU) is one of the most potent antimetabolites which have been widely used in the treatment of advanced solid tumors. As an anticancer agent, because of its low efficacy and high toxicity, numerous modifications of 5-FU structure have been performed. A great number of novel 5-FU derivatives have been developed with highly efficient and much less toxic. In this paper, the recent development of novel 5-FU derivatives as potent antitumor agents is reviewed and discussed.
5-氟尿嘧啶（5-FU）是最有效的抗代谢物之一，已广泛用于治疗晚期实体瘤。作为一种抗癌药物，由于其疗效低、毒性高，对其结构进行了大量修饰。开发了许多新型 5-FU 衍生物，具有高效低毒的特点。本文综述并讨论了新型 5-FU 衍生物作为有效抗肿瘤药物的研究进展。
