Research Unit in Molecular Biology (URBM), NARILIS, University of Namur, Namur, Belgium.
FEBS Lett. 2011 Oct 3;585(19):2929-34. doi: 10.1016/j.febslet.2011.08.011. Epub 2011 Aug 19.
"In vivo" bacterial nutrition, i.e. the nature of the metabolic network and substrate(s) used by bacteria within their host, is a fundamental aspect of pathogenic or symbiotic lifestyles. A typical example are the Brucella spp., facultative intracellular pathogens responsible for chronic infections of animals and humans. Their virulence relies on their ability to modulate immune response and the physiology of host cells, but the fine-tuning of their metabolism in the host during infection appears increasingly crucial. Here we review new insights on the links between Brucella virulence and metabolism, pointing out the need to investigate both aspects to decipher Brucella infectious strategies.
“体内”细菌营养，即细菌在其宿主内使用的代谢网络的性质和（或）基质，是其致病性或共生性生活方式的一个基本方面。一个典型的例子是布鲁氏菌属，兼性细胞内病原体，可导致动物和人类的慢性感染。它们的毒力依赖于它们调节免疫反应和宿主细胞生理学的能力，但在感染过程中它们在宿主中的代谢精细调节似乎变得越来越重要。在这里，我们综述了布鲁氏菌毒力与代谢之间联系的新见解，指出需要同时研究这两个方面来破解布鲁氏菌的感染策略。
