Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK.
Neuropharmacology. 2012 Mar;62(3):1164-7. doi: 10.1016/j.neuropharm.2011.08.009. Epub 2011 Aug 16.
Genetic mouse models relevant to schizophrenia complement, and have to a large extent supplanted, pharmacological and lesion-based rat models. The main attraction is that they potentially have greater construct validity; however, they share the fundamental limitations of all animal models of psychiatric disorder, and must also be viewed in the context of the uncertain and complex genetic architecture of psychosis. Some of the key issues, including the choice of gene to target, the manner of its manipulation, gene-gene and gene-environment interactions, and phenotypic characterization, are briefly considered in this commentary, illustrated by the relevant papers reported in this special issue.
与精神分裂症相关的遗传小鼠模型是对药理学和损伤性大鼠模型的补充，在很大程度上也取代了它们。其主要吸引力在于它们具有更大的结构有效性；然而，它们也存在所有精神疾病动物模型的基本局限性，并且必须结合精神分裂症不确定和复杂的遗传结构来进行观察。本文简要讨论了一些关键问题，包括靶基因的选择、其操作方式、基因-基因和基因-环境相互作用以及表型特征等，并用本特刊中报道的相关论文进行了说明。
