Department of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.
Peptides. 2012 Mar;34(1):51-6. doi: 10.1016/j.peptides.2011.08.005. Epub 2011 Aug 12.
The corpora cardiaca of the Vietnamese stick insect, Baculum extradentatum, contain a member of the adipokinetic hormone/red pigment-concentrating hormone/hypertrehalosemic hormone (AKH/RPCH/HrTH) family of peptides whose sequence is identical to that originally described for the Indian stick insect, Carausius morosus. This decapeptide, Carmo-HrTH-II (pELTFTPNWGTa), has both hypertrehalosemic and cardioacceleratory activity in B. extradentatum, and hyperlipaemic activity in locusts. Reversed-phase high performance liquid chromatography (RP-HPLC) of corpora cardiaca extract followed by MALDI-TOF MS/MS also revealed a novel modification of a second peptide in B. extradentatum: the tryptophan residue at position 8 is post-translationally modified to kynurenine.
越南竹节虫的脑神经分泌器官中含有一种激素家族成员，即脂肪激素/红色素集中激素/高血糖素（AKH/RPCH/HrTH）家族肽，其序列与印度竹节虫 Carausius morosus 最初描述的序列完全相同。这种十肽 Carmo-HrTH-II (pELTFTPNWGTa) 在 B. extradentatum 中具有高血糖素和心脏加速活性，并且在蝗虫中具有高脂血症活性。心脏分泌器官提取物的反相高效液相色谱 (RP-HPLC) 后，通过 MALDI-TOF MS/MS 还揭示了 B. extradentatum 中第二种肽的一种新修饰：第 8 位色氨酸残基被翻译后修饰为犬尿氨酸。
