Laboratorio de Química Fina, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), Universidad Nacional del Litoral and Consejo Nacional de Investigaciones Científicas y Técnicas (UNL-CONICET), CCT CONICET-SANTA FE, Ruta Nacional 168, Paraje El Pozo, 3000 Santa Fe, Argentina.
Eur J Pharm Sci. 2011 Oct 9;44(3):288-98. doi: 10.1016/j.ejps.2011.08.008. Epub 2011 Aug 16.
A mathematical modeling of controlled release of drug from one-layer and two-layer torus-shaped devices with external mass transfer resistance is presented. Analytical solutions based on the pseudo-steady state approximation are derived. The validity of the equations is established in two stages. In the first stage, the validity of the models derived for more complex systems is determined by comparison with profiles predicted by the simplest model, in asymptotic cases. In the second stage, the reliability and usefulness of the models are ascertained by comparison of the simulation results with vaginal rings experimental release data reported in the literature. In order to measures quantitatively the fit of the theoretical models to the experimental data, the pair-wise procedure is used. A good agreement between the prediction of the models and the experimental data is observed. The models are applicable only to torus-shaped systems in where the initial load of drug is higher than its solubility in the polymer.
本文提出了一种具有外部传质阻力的单层和双层环形容器中药物控制释放的数学模型。基于准稳态近似的解析解。通过与最简单模型预测的渐近情况的剖面进行比较，确定了方程的有效性。在第二阶段，通过将模拟结果与文献中报道的阴道环实验释放数据进行比较，确定了模型的可靠性和实用性。为了定量衡量理论模型与实验数据的拟合程度，采用了成对方法。模型的预测与实验数据吻合较好。该模型仅适用于初始药物负荷高于聚合物溶解度的环形容器系统。
