Terry Fox Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, Canada.
Curr Opin Immunol. 2011 Oct;23(5):564-72. doi: 10.1016/j.coi.2011.08.001. Epub 2011 Aug 22.
Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein to orchestrate the innate host response to pathogen, ultimately leading to the induction of antiviral and inflammatory responses mediated by type I interferon (IFN) and NF-κB pathways. MAVS is localized to the outer mitochondrial membrane, and has been associated with peroxisomes, the endoplasmic reticulum and autophagosomes, where it coordinates signaling events downstream of RLRs. MAVS not only plays a pivotal role in the induction of antiviral and inflammatory pathways but is also involved in the coordination of apoptotic and metabolic functions. This review summarizes recent findings related to the MAVS adapter and its essential role in the innate immune response to RNA viruses.
RLR 识别 RNA 病毒感染，引发复杂的信号级联反应，利用线粒体抗病毒信号（MAVS）衔接蛋白，协调先天宿主对病原体的反应，最终诱导 I 型干扰素（IFN）和 NF-κB 通路介导的抗病毒和炎症反应。MAVS 定位于外线粒体膜，与过氧化物酶体、内质网和自噬体相关，在这些部位，它协调 RLRs 下游的信号事件。MAVS 不仅在诱导抗病毒和炎症途径中发挥关键作用，还参与协调细胞凋亡和代谢功能。本综述总结了与 MAVS 衔接蛋白及其在 RNA 病毒先天免疫反应中的重要作用相关的最新发现。
