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CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.

作者信息

Choi Serah, Toledo Luis I, Fernandez-Capetillo Oscar, Bakkenist Christopher J

出版信息

DNA Repair (Amst). 2011 Oct 10;10(10):1000-1; author reply 1002. doi: 10.1016/j.dnarep.2011.07.013. Epub 2011 Aug 23.

Abstract
摘要

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本文引用的文献

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A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.
Nat Struct Mol Biol. 2011 Jun;18(6):721-7. doi: 10.1038/nsmb.2076. Epub 2011 May 8.
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Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.
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ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.
J Radiat Res. 2010;51(4):417-22. doi: 10.1269/jrr.10015. Epub 2010 Apr 24.
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DNA-PKcs and ATM co-regulate DNA double-strand break repair.
DNA Repair (Amst). 2009 Aug 6;8(8):920-9. doi: 10.1016/j.dnarep.2009.05.006. Epub 2009 Jun 16.
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Retraction: small molecule-based reversible reprogramming of cellular lifespan.
Nat Chem Biol. 2008 Jul;4(7):431. doi: 10.1038/nchembio0708-431.
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Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.
Cell Cycle. 2008 May 1;7(9):1277-84. doi: 10.4161/cc.7.9.5961. Epub 2008 Mar 18.
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Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin.
DNA Repair (Amst). 2008 Apr 2;7(4):582-96. doi: 10.1016/j.dnarep.2007.12.012. Epub 2008 Mar 4.

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