CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.
作者信息
Choi Serah, Toledo Luis I, Fernandez-Capetillo Oscar, Bakkenist Christopher J
出版信息
DNA Repair (Amst). 2011 Oct 10;10(10):1000-1; author reply 1002. doi: 10.1016/j.dnarep.2011.07.013. Epub 2011 Aug 23.
Abstract
摘要
相似文献
1
CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.CGK733在H460人肺癌细胞中不抑制ATM或ATR激酶活性。
DNA Repair (Amst). 2011 Oct 10;10(10):1000-1; author reply 1002. doi: 10.1016/j.dnarep.2011.07.013. Epub 2011 Aug 23.
2
ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.ATM 是热激后导致组蛋白 H2AX 磷酸化的主要激酶。
J Radiat Res. 2010;51(4):417-22. doi: 10.1269/jrr.10015. Epub 2010 Apr 24.
3
The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.ATM 和 ATR 抑制剂 CGK733 和咖啡因降低细胞周期蛋白 D1 水平并抑制细胞增殖。
Radiat Oncol. 2009 Nov 10;4:51. doi: 10.1186/1748-717X-4-51.
4
Small molecule-based reversible reprogramming of cellular lifespan.基于小分子的细胞寿命可逆重编程
Nat Chem Biol. 2006 Jul;2(7):369-74. doi: 10.1038/nchembio800. Epub 2006 Jun 11.
5
Molecular imaging of the ATM kinase activity.ATM 激酶活性的分子成像。
Int J Radiat Oncol Biol Phys. 2013 Aug 1;86(5):969-77. doi: 10.1016/j.ijrobp.2013.04.028. Epub 2013 May 29.
6
Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy.共济失调毛细血管扩张症突变基因和p21CIP1调节药物诱导的衰老肿瘤细胞的细胞存活：对化疗的启示。
Clin Cancer Res. 2008 Mar 15;14(6):1877-87. doi: 10.1158/1078-0432.CCR-07-4298.
7
Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated.吉非替尼通过抑制共济失调毛细血管扩张突变基因使非小细胞肺癌细胞辐射敏感。
Mol Cancer. 2010 Aug 23;9:222. doi: 10.1186/1476-4598-9-222.
8
Enhanced radiation-mediated cell killing of human cervical cancer cells by small interference RNA silencing of ataxia telangiectasia-mutated protein.通过小干扰RNA沉默共济失调毛细血管扩张突变蛋白增强辐射介导的人宫颈癌细胞杀伤作用
Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1620-30. doi: 10.1111/j.1525-1438.2006.00636.x.
9
CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells.CGK733 增强 Chk1 缺陷型 HBV 阳性肝癌细胞中紫杉醇诱导的多核细胞形成和细胞毒性。
Biochem Biophys Res Commun. 2012 May 25;422(1):103-8. doi: 10.1016/j.bbrc.2012.04.115. Epub 2012 Apr 30.
10
Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells.共济失调毛细血管扩张突变基因（ATM）抑制可改变人乳腺上皮细胞。
J Biol Chem. 2010 Apr 23;285(17):13092-106. doi: 10.1074/jbc.M109.078360. Epub 2010 Feb 22.
引用本文的文献
1
Molecular Connections between DNA Replication and Cell Death in β-Amyloid-Treated Neurons.β-淀粉样蛋白处理神经元中 DNA 复制与细胞死亡的分子联系。
Curr Neuropharmacol. 2023;21(9):2006-2018. doi: 10.2174/1570159X21666230404121903.
2
The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells.ATM和Chk1抑制剂联合使用可诱导大肠癌细胞产生合成致死效应。
Cancers (Basel). 2023 Jan 25;15(3):735. doi: 10.3390/cancers15030735.
3
From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases.从酵母到人类：了解DNA损伤反应（DDR）激酶的生物学特性
Genet Mol Biol. 2019 Dec 13;43(1 suppl 1):e20190071. doi: 10.1590/1678-4685-GMB-2019-0071. eCollection 2019.
4
APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression.APOBEC3B 报告骨髓瘤细胞系鉴定导致 APOBEC3B 表达的 DNA 损伤反应途径。
PLoS One. 2020 Jan 8;15(1):e0223463. doi: 10.1371/journal.pone.0223463. eCollection 2020.
5
ATM, ATR, CHK1, CHK2 and WEE1 inhibitors in cancer and cancer stem cells.癌症及癌症干细胞中的ATM、ATR、CHK1、CHK2和WEE1抑制剂
Medchemcomm. 2016 Nov 30;8(2):295-319. doi: 10.1039/c6md00439c. eCollection 2017 Feb 1.
6
The Human Papillomavirus E6 PDZ Binding Motif Links DNA Damage Response Signaling to E6 Inhibition of p53 Transcriptional Activity.人乳头瘤病毒 E6 PDZ 结合基序将 DNA 损伤反应信号与 E6 抑制 p53 转录活性联系起来。
J Virol. 2018 Jul 31;92(16). doi: 10.1128/JVI.00465-18. Print 2018 Aug 15.
7
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.ATR 和 CHK1 激酶活性之间的肿瘤特异性合成致死性。
Cell Rep. 2016 Jan 12;14(2):298-309. doi: 10.1016/j.celrep.2015.12.032. Epub 2015 Dec 31.
8
Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising.靶向DNA双链断裂修复途径的化疗化合物：益处、弊端与前景。
Front Oncol. 2014 Apr 22;4:86. doi: 10.3389/fonc.2014.00086. eCollection 2014.
9
The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.鸡视网膜Lim1水平细胞的异质性终末细胞周期不受DNA损伤反应途径的调控。
Cell Cycle. 2014;13(3):408-17. doi: 10.4161/cc.27200. Epub 2013 Nov 18.
本文引用的文献
1
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.基于细胞的筛选鉴定出对与癌症相关突变具有合成致死特性的 ATR 抑制剂。
Nat Struct Mol Biol. 2011 Jun;18(6):721-7. doi: 10.1038/nsmb.2076. Epub 2011 May 8.
2
Effects of titanocene dichloride derivatives on prostate cancer cells, specifically DNA damage-induced apoptosis.二氯二茂钛衍生物对前列腺癌细胞的影响，特别是诱导 DNA 损伤的细胞凋亡。
Prostate. 2011 Feb 1;71(2):111-24. doi: 10.1002/pros.21227.
3
Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.瞬时 ATM 激酶抑制破坏了 DNA 损伤诱导的姐妹染色单体交换。
Sci Signal. 2010 Jun 1;3(124):ra44. doi: 10.1126/scisignal.2000758.
4
ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.ATM 是热激后导致组蛋白 H2AX 磷酸化的主要激酶。
J Radiat Res. 2010;51(4):417-22. doi: 10.1269/jrr.10015. Epub 2010 Apr 24.
5
The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.ATM 和 ATR 抑制剂 CGK733 和咖啡因降低细胞周期蛋白 D1 水平并抑制细胞增殖。
Radiat Oncol. 2009 Nov 10;4:51. doi: 10.1186/1748-717X-4-51.
6
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.改良的 ATM 激酶抑制剂 KU-60019 增敏脑胶质瘤细胞放疗敏感性，削弱胰岛素、AKT 和 ERK 促生存信号，并抑制迁移和侵袭。
Mol Cancer Ther. 2009 Oct;8(10):2894-902. doi: 10.1158/1535-7163.MCT-09-0519. Epub 2009 Oct 6.
7
DNA-PKcs and ATM co-regulate DNA double-strand break repair.DNA依赖蛋白激酶催化亚基（DNA-PKcs）与共济失调毛细血管扩张突变蛋白（ATM）共同调节DNA双链断裂修复。
DNA Repair (Amst). 2009 Aug 6;8(8):920-9. doi: 10.1016/j.dnarep.2009.05.006. Epub 2009 Jun 16.
8
Retraction: small molecule-based reversible reprogramming of cellular lifespan.撤稿：基于小分子的细胞寿命可逆重编程。
Nat Chem Biol. 2008 Jul;4(7):431. doi: 10.1038/nchembio0708-431.
9
Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.在缺乏ATM激酶活性的情况下，不可逆的染色体损伤会迅速累积。
Cell Cycle. 2008 May 1;7(9):1277-84. doi: 10.4161/cc.7.9.5961. Epub 2008 Mar 18.
10
Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin.在顺铂和奥沙利铂处理的DNA聚合酶η缺陷型人类细胞中，DNA依赖蛋白激酶介导的RPA2过度磷酸化增强。
DNA Repair (Amst). 2008 Apr 2;7(4):582-96. doi: 10.1016/j.dnarep.2007.12.012. Epub 2008 Mar 4.
Zotero 插件