Section on Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.
J Clin Invest. 2011 Sep;121(9):3395-7. doi: 10.1172/JCI58899. Epub 2011 Aug 25.
For decades, investigators have made numerous attempts to generate human pancreatic β cell lines that could be used to advance β cell biology, facilitate drug discovery, and provide a pathway to β cell replacement therapy for the treatment of diabetes. In this issue of the JCI, Ravassard and colleagues report that this has finally been achieved successfully with a multistep process that led to the generation of cells, which they termed EndoC-βH1 cells, that secreted insulin in response to glucose challenge.
几十年来，研究人员进行了多次尝试，以生成可用于推进β细胞生物学、促进药物发现以及为糖尿病的β细胞替代治疗提供途径的人胰腺β细胞系。在本期 JCI 中，Ravassard 及其同事报告称，他们终于成功地通过多步过程实现了这一目标，生成了他们称之为 EndoC-βH1 细胞的细胞，这些细胞在受到葡萄糖刺激时会分泌胰岛素。
