终于！有了人类胰腺β细胞系。
Finally! A human pancreatic β cell line.
机构信息
Section on Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.
出版信息
J Clin Invest. 2011 Sep;121(9):3395-7. doi: 10.1172/JCI58899. Epub 2011 Aug 25.
Abstract
For decades, investigators have made numerous attempts to generate human pancreatic β cell lines that could be used to advance β cell biology, facilitate drug discovery, and provide a pathway to β cell replacement therapy for the treatment of diabetes. In this issue of the JCI, Ravassard and colleagues report that this has finally been achieved successfully with a multistep process that led to the generation of cells, which they termed EndoC-βH1 cells, that secreted insulin in response to glucose challenge.
摘要
几十年来，研究人员进行了多次尝试，以生成可用于推进β细胞生物学、促进药物发现以及为糖尿病的β细胞替代治疗提供途径的人胰腺β细胞系。在本期 JCI 中，Ravassard 及其同事报告称，他们终于成功地通过多步过程实现了这一目标，生成了他们称之为 EndoC-βH1 细胞的细胞，这些细胞在受到葡萄糖刺激时会分泌胰岛素。
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本文引用的文献
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