Meluzín J, Lupínek Z, Lupínková Z
Krajský ústav národního zdravi, I. interní klinika FNsP Brno.
Vnitr Lek. 1990 Feb;36(2):134-40.
In a simple blind crossover 7-week study with a randomized beginning the authors compared in 13 patients with stable angina pectoris after exercise the action of diltiazem (Blocalcin 60, Lachema) and isosorbidedi nitrate (Isoket retard 120, Schwarz). Both drugs improved significantly, as compared with placebo, the tolerance of the load, reduced the frequency of stenocardias per 24 hours, diltiazem also the nitroglycerin consumption per 24 hours. Diltiazem reduced significantly, as compared with isosorbidedi nitrate, the pulse rate at rest, it reduced significantly Robinson's index and the diastolic pressure at rest. In none of the other investigated parameters there was a significant difference between the two drugs and both are valuable in the treatment of angina after exercise. Diltiazem was well tolerated by the patients, while headache was a frequent side-effect of isosorbide dinitrate.
在一项为期7周的简单双盲交叉研究中，研究开始时进行了随机分组，作者比较了13例运动后稳定型心绞痛患者使用地尔硫䓬（波依定60，拉赫马）和硝酸异山梨酯（长效异乐定120，施瓦茨）的效果。与安慰剂相比，两种药物均显著改善了运动耐量，降低了每24小时心绞痛发作的频率，地尔硫䓬还降低了每24小时硝酸甘油的消耗量。与硝酸异山梨酯相比，地尔硫䓬显著降低了静息心率，显著降低了罗宾逊指数和静息舒张压。在其他研究参数中，两种药物之间均无显著差异，且两者在运动后心绞痛的治疗中均有价值。患者对地尔硫䓬耐受性良好，而头痛是硝酸异山梨酯常见的副作用。
